How Types of Kidney Cancer Can Differ, and Why It Matters
Kidney cancer may sound straightforward (after all, your kidneys are distinct organs), but there are several subtypes that can complicate diagnosis and treatment. Depending on your risk factors, age, genetic predisposition, and symptoms, your treatment and outlook could be much different than another kidney cancer patient.
Symptoms of kidney cancer can differ depending on the specific type. Where the tumor is located, how it grows, and how fast it grows will determine which symptoms — if any — you experience in the earlier stages.
However, your doctor will be able to narrow down the type with a consultation and some close examination. Understanding the different types of kidney cancer is the first step toward effective treatment and care.
Kidney Cancer in Adults and Children
Different forms of kidney cancer can affect anyone at any age, but some types are more likely to affect certain age groups. In adults, the most common type is renal carcinoma, but more children suffer from Wilms’ tumor more than other types of kidney cancer.
There are some key differences between kidney cancer in adults and kidney cancer in children:
- Childhood cancers often come from DNA changes in cells at a very early stage of development
- Cancer in adults is more often linked to environment and lifestyle factors (as well as genetics)
- Children often respond better to chemotherapy treatments
- Adults can more fully recover from invasive treatments like chemotherapy
Four Major Types of Kidney Cancer
Like many cancers, kidney cancer can take several forms. However, there are four main categories of kidney cancer, distinguished by where the cancer manifests and how it spreads.
Renal Cell Carcinoma (RCC)
By far the most common type of kidney cancer, renal cell carcinoma is to blame for around 90 percent of cases. It usually takes the form of a tumor that grows in the lining of the tubules inside the kidney. Often there is just one tumor, but renal cell carcinoma can manifest in two or three tumors in one or both kidneys.
This type of kidney cancer can be further divided into five categories. The two most common are:
- Clear cell. Almost three-quarters of people with RCC suffer from this type. It can be slow growing or fast growing, and is associated with von Hippel-Lindau syndrome.
- Papillary kidney cancer. The second most common type, papillary kidney cancer accounts for about 10 percent of all cases. It is associated with two hereditary syndromes: hereditary papillary RCC and hereditary leiomyomatosis RCC.
Some cases of RCC kidney cancers do not fall into any of the categories, or have characteristics of more than one type. These cases are known as unclassified renal cell carcinomas and can be aggressive and difficult to control.
Most people diagnosed with RCC are between the ages of 50 and 70. As kidney cancer progresses, these specific symptoms might arise:
- A lump on your side or belly (caused by the growing tumor)
- Low back pain
- Blood in the urine
- High blood pressure
Other more general cancer symptoms can come with the kidney-specific signs, like unexplained weight loss, fatigue, fever, night sweats, and anemia.
However, there is often another explanation for the back or belly pain (and many of the other symptoms), so although it’s important to see your doctor with any worrying changes, don’t assume the worst. Moreover, RCC caught early on can often be very successfully treated.
Wilms’ Tumor (Nephroblastoma)
The most common type of childhood kidney cancer is still relatively rare: Wilms’ tumor accounts for about seven percent of all childhood cancers in the U.S. Generally, this type of cancer is found before age five.
Most Wilms’ tumors are found only in one kidney, and there is usually only one tumor. However, in between five and 10 percent of cases, there are two or more tumors on the one kidney. Only five percent of children with this type of kidney cancer have tumors in both kidneys.
Luckily, most Wilms’ tumors are found before they have spread to other organs, but they usually grow quite large before they are discovered — often bigger than the kidney itself.
Next page: how different types of kidney cancer are treated.